Actually, while you might have found that comment silly, I actually found it to be one of the most moving of Tron: Legacy. In fact, I found it rather tragic.
It is a foundation for how alien and strange the Grid can be. It opens the rift between the minds and existence of User and Program: to the assumptions, ways of thought, and fundamental complexity (and relative chaos) of existence which we contend with - and which, as a race, we can only hope to glimpse. Science, art, society, it all helps to reveal greater secrets and challenges for us.
.... Programs do not have this. Inherently, they are relatable, but they are not like us. So far as we know, there is no calling of mystery and greater Grid universe beyond their avenues of function. Even the matter of the Grid itself seems to lack the staggering depth of which literally permeates every inch of our own world. Programs are said to revere Users - Users not only have great power, but they hail from a world which is compelling and strange, full of wonders, potential, and mystery.
"The universe in a grain of sand" does not hold on the Grid, and it's people cannot experience it in the same way. Perhaps one day Tron: Uprising will have begun to explore the deeper currents of the Grid, and the potential, curiosity, and knowledge of it's Programs - and it's founding figures, Clu and Tron.