Usually, that error means the .REZ files are in use by some program, so REZ Handler can't do anything with them as long as that program has them open/is using them. Normally, that would be the game. But it could have been some other program at the time.
If you've restarted your computer in the meantime, you might find it just simply works now.
Also, run the game launcher (not the Mod Manager) and click the Custom button. There should be an X in the box beside the word Retail.
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